IBX-4041, A Chromogenic Substrate of Neuraminidases (Sialidases)

Synthesis of IBX-4041 and its application in detection of neuraminidases (sialidases) are documented in 2000 by Jonson at el.1  This compound is a glycoside containing N-acetylneuraminic acid and thymolphthalein units, which are linked together by a glycosidic bond. IBX-4041 is considered a chromogenic substrate since it displays color change upon hydrolysis by the enzymes, namelyContinue reading “IBX-4041, A Chromogenic Substrate of Neuraminidases (Sialidases)”

Bacterial Vaginosis and Methods for Its Diagnosis

Bacterial vaginosis (BV), trichomoniasis, and vulvovaginal candidiasis are three most common infectious causes of vaginitis.  In BV patients, the “normal” and beneficial bacteria dominated by hydrogen peroxide-producing lactobacilli are replaced by the “abnormal” and harmful bacteria such as Gardnerella vaginalis, Mycoplasma hominis, and anaerobes Bactoides spp. and Prevotella spp. If left untreated, BV is knownContinue reading “Bacterial Vaginosis and Methods for Its Diagnosis”